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Clinical Research & Studies

The amniotic membrane can be a valid source for wound healing.

From the US Library of Medicine at the National Institutes of Health.

From the NIH Research Study:

AM graft can be an ideal choice instead of tissue-engineered skin equivalents to be used in wound healing. In addition to being an excellent scaffold, it has unique biological properties that are important for tissue repair, including anti-inflammatory, antimicrobial, antifibrosis, antiscarring, as well as a reasonable cost and low immunogenicity. Furthermore, presence of its own progenitor cells helps in tissue repair.

From a Study Reported in BMC Surgery:

In prospective and retrospective studies, it was shown that large chronic ulcers which were resistant to closure with standard therapy achieved wound closure with amniotic membrane allografts.

From a Study Reported in the International Wound Journal:

The most obvious finding from the analysis was that HAM (human amniotic membrane) plus SOC (standard of care) did accelerate the process of wound healing. HAM plus SOC achieved a much higher probability of wound recovery than SOC alone, about four times at 6 weeks and two times at 12 weeks. It also had a significantly shorter time to complete wound closure, about 30 days earlier.

From the Study Wounds: A Compendium of Clinical Research and Practice:

Amnion/chorion membranes have been studied in the treatment of burns, diabetic foot ulcers, fistulas, ocular defects, and venous leg ulcers, among other wounds. Amnion/chorion allografts were found to be beneficial in the setting of difficult-to-heal fistulas and were effective in treating diabetic and venous ulcers when combined with standard therapy.

A Study Reported in the Journal of Wound Care:

Amniotic membrane was applied to a series of chronic wounds referred to a formal wound clinic for aggressive management, after prior, traditional treatment methods were found ineffective, over a period of 1 month. In each case, failure of traditional therapy was followed by placement of a dehydrated amniotic membrane allograft and the healing time course was documented with charted measurements. Wounds treated with the amniotic membrane allograft demonstrated improved healing, with a change in the healing trajectory from that previously noted.